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BAG 1 predicts patient outcome and tamoxifen responsiveness in ER positive invasive ductal carcinoma of the breast
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Top of pageAbstractBAG 1 (bcl 2 associated athanogene) enhances oestrogen receptor (ER) function and may influence outcome and response to endocrine therapy in breast cancer. We determined relationships between BAG 1 expression,[url=http://www.new--balance.fr/]new balance 574[/url], molecular phenotype,[url=http://www.abercrombieand-fitch@#$%&/]hollister california[/url], response to tamoxifen therapy and outcome in a cohort of breast cancer patients and its influence on tamoxifen sensitivity in MCF 7 breast cancer cells in vitro. Publically available gene expression data sets were analysed to identify relationships between BAG 1 mRNA expression and patient outcome. BAG 1 protein expression was assessed using immunohistochemistry in 292 patients with invasive ductal carcinoma and correlated with clinicopathological variables, therapeutic response and disease outcome. BAG 1 overexpressing MCF 7 cells were treated with antioestrogens to assess its effects on cell proliferation. Gene expression data demonstrated a consistent association between high BAG 1 mRNA and improved survival. In ER cancer (n a high nuclear BAG 1 expression independently predicted improved outcome for local recurrence (P distant metastases (P death from breast cancer (P hazards ratio 0.29, 95 CI: 0.114 and improved outcome in tamoxifen treated patients (n P BAG 1 overexpression in MCF 7 cells augmented antioestrogen induced growth arrest. A high BAG 1 expression predicts improved patient outcome in ER breast carcinoma.

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